BAM15 Capsules

Recommended dosage

Take 1 capsule per day for the first week, 2 capsules per day thereafter. Use before breakfast. One bottle should last 30 days - 60 days

Detailed Product Information- About BAM15

BAM15 is a mitochondrial uncoupler that has shown potential in various research areas, including obesity, kidney injury, and cancer treatment. It works by increasing energy expenditure and metabolic flexibility, and it has been shown to have less cytotoxicity compared to other uncouplers.

Here's a more detailed breakdown

What it is: BAM15 is a small molecule that acts as a protonophore, meaning it facilitates the movement of protons across the mitochondrial membrane. This process uncouples oxidative phosphorylation, the process that normally couples nutrient metabolism to ATP (energy) production.

How it works

Increases energy expenditure: By uncoupling oxidative phosphorylation, BAM15 allows for increased oxygen consumption and substrate oxidation, leading to higher energy expenditure.

Modulates metabolism: BAM15 can improve body composition and glycemic control, even without significant weight loss.

Protects against kidney injury: Studies have shown that BAM15 can protect against kidney damage from ischemia-reperfusion injury and cold storage damage.

Potential for other treatments: BAM15 is being explored for potential use in treating obesity, sepsis, and cancer.

Key properties

Cell penetrant and potent: BAM15 can easily enter cells and effectively uncouple mitochondria.

Less cytotoxic: Compared to other uncouplers, BAM15 has shown reduced cytotoxicity.

Targets specific pathways: It can activate signaling pathways like AMPK and PGC-1α, which are involved in cellular energy metabolism.

Short half-life: BAM15 has a relatively short half-life in the body, requiring sustained delivery for prolonged effects.

Research areas

Obesity and metabolic disorders: BAM15 has shown promise in animal models for reducing obesity and improving glycemic control.

Kidney disease: It has demonstrated protective effects against kidney injury in various models.

Cancer: Research suggests BAM15 may have potential in cancer treatment by affecting mitochondrial function and inducing apoptosis.

Sepsis: BAM15 has been shown to be effective in treating sepsis in mouse models.

Neurodegeneration: Studies in C. elegans suggest BAM15 may have a role in relieving neurodegeneration and extending lifespan.

Vascular health: BAM15 has been shown to inhibit artery constriction and activate AMPK in vascular smooth muscle cells.

Immune function: BAM15 can modulate immune responses, potentially by affecting inflammation and neutrophil infiltration.

Side Effects - SELDOM SEEN OR REPORTED

• Elevated body temperature / risk of hyperthermia
• Fatigue and low energy if caloric intake doesn’t match increased burn
• Possible oxidative stress and mitochondrial strain
• Gastrointestinal upset (nausea, discomfort, diarrhea – theoretical)
• Potential liver strain (seen in some mitochondrial uncouplers)
• Possible negative impact on heart health if metabolism is pushed too high
• Risk of dehydration due to higher energy expenditure